Anti-AIFM1 Polyclonal Antibody
- 發(fā)布日期： 2019-05-13
- 更新日期： 2025-07-11
產(chǎn)品詳請
| 產(chǎn)地 |
北京
|
| 品牌 |
Solarbio
|
| 保存條件 |
Store at -20°C. Avoid freeze / thaw cycles.
|
| 貨號 |
K106409P
|
| 應(yīng)用范圍 |
WB
|
| CAS編號 |
|
| 抗體名 |
Anti-AIFM1 Polyclonal Antibody
|
| 克隆性 |
Polyclonal Antibody
|
| 靶點(diǎn) |
SDHA
|
| 適應(yīng)物種 |
Human Mouse Rat
|
| 形態(tài) |
|
| 宿主 |
Rabbit
|
| 亞型 |
IgG
|
| 標(biāo)識物 |
AIF;PDCD8;CMT2D;CMTX4;COWCK;COXPD6;DFNX5;NADMR;NAMSD
|
| 濃度 |
%
|
| 免疫原 |
A synthetic peptide of human AIFM1
|
Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
