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北京索萊寶科技有限公司
產(chǎn)品展廳
Anti-AIF Polyclonal Antibody
  • 品牌:Solarbio
  • 產(chǎn)地:北京
  • 貨號(hào):K106588P
  • 發(fā)布日期: 2019-05-13
  • 更新日期: 2025-07-11
產(chǎn)品詳請(qǐng)
產(chǎn)地 北京
品牌 Solarbio
保存條件 Store at -20°C. Avoid freeze / thaw cycles.
貨號(hào) K106588P
應(yīng)用范圍 WB
CAS編號(hào)
抗體名 Anti-AIF Polyclonal Antibody
克隆性 Polyclonal Antibody
靶點(diǎn)
適應(yīng)物種 Human Mouse Rat
形態(tài)
宿主 Rabbit
亞型 IgG
標(biāo)識(shí)物 AIFM1;CMT2D;CMTX4;COWCK;COXPD6;DFNX5;NADMR;NAMSD;PDCD8
濃度 %
免疫原 Recombinant protein of human AIF
Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
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