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北京索萊寶科技有限公司
產(chǎn)品展廳
Anti-MADH7 Polyclonal Antibody
  • 品牌:Solarbio
  • 產(chǎn)地:北京
  • 貨號:K106646P
  • 發(fā)布日期: 2019-05-13
  • 更新日期: 2025-07-10
產(chǎn)品詳請
產(chǎn)地 北京
品牌 Solarbio
保存條件 Store at -20°C. Avoid freeze / thaw cycles.
貨號 K106646P
應(yīng)用范圍 IHC
CAS編號
抗體名 Anti-MADH7 Polyclonal Antibody
克隆性 Polyclonal Antibody
靶點(diǎn)
適應(yīng)物種 Human
形態(tài)
宿主 Rabbit
亞型 IgG
標(biāo)識物 CRCS3;MADH7;MADH8;Hsmad7;MAD homolog 8
濃度 %
免疫原 A synthetic peptide of human MADH7
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
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