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北京索萊寶科技有限公司
產(chǎn)品展廳
Anti-NR1H4 Polyclonal Antibody
  • 品牌:Solarbio
  • 產(chǎn)地:北京
  • 貨號(hào):K107059P
  • 發(fā)布日期: 2019-05-13
  • 更新日期: 2025-07-08
產(chǎn)品詳請(qǐng)
產(chǎn)地 北京
品牌 Solarbio
保存條件 Store at -20°C. Avoid freeze / thaw cycles.
貨號(hào) K107059P
應(yīng)用范圍 IHC
CAS編號(hào)
抗體名 Anti-NR1H4 Polyclonal Antibody
克隆性 Polyclonal Antibody
靶點(diǎn)
適應(yīng)物種 Human Mouse
形態(tài)
宿主 Rabbit
亞型 IgG
標(biāo)識(shí)物 Bile acid receptor;BAR;FXR;HRR1;RIP14
濃度 %
免疫原 A synthetic peptide of human NR1H4
Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid, deoxycholic acid and allocholic acid. Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response. The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands.
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