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北京索萊寶科技有限公司
產(chǎn)品展廳
Anti-DFFB Polyclonal Antibody
  • 品牌:Solarbio
  • 產(chǎn)地:北京
  • 貨號:K106875P
  • 發(fā)布日期: 2019-05-13
  • 更新日期: 2025-07-08
產(chǎn)品詳請
產(chǎn)地 北京
品牌 Solarbio
保存條件 Store at -20°C. Avoid freeze / thaw cycles.
貨號 K106875P
應(yīng)用范圍 IHC
CAS編號
抗體名 Anti-DFFB Polyclonal Antibody
克隆性 Polyclonal Antibody
靶點
適應(yīng)物種 Human
形態(tài)
宿主 Rabbit
亞型 IgG
標(biāo)識物 CAD;CPAN;DFF-40;DFF2;DFF40;DNA fragmentation factor subunit beta
濃度 %
免疫原 A synthetic peptide of human DFFB
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD and 45-kD subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined.
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